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Permeation Models and Structure-function Relationships in Ion Channels

Kuyucak, Serdar; Chung, Shin-Ho

Description

Recent determination of the molecular structures of potassium and mechanosensitive channels from x-ray crystallography has led to a renewed interest in ion channels. The challenge for permeation models is to understand the functional properties of channels from the available structural information. Here we give a critical review of the three main contenders, namely, continuum theories, Brownian dynamics and molecular dynamics. Continuum theories are shown to be invalid in a narrow channel...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/71604
Source: Journal of Biological Physics
DOI: 10.1023/A:1019939900568

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