The role of histidine-rich glycoprotein in necrotic cell clearance and regulation of degradative enzymes
Histidine-rich glycoprotein (HRG) is an abundant multi-functional protein that is present in the plasma of many vertebrates. HRG has a multi-domain structure that allows the molecule to interact with many ligands including heparin, heparan sulfate (HS), Fcy receptors (FcyR), plasminogen, fibrinogen, IgG, Clq, haem and Zn2+. The ability of HRG to interact with various ligands simultaneously has suggested that HRG can act as an adaptor molecule and regulate numerous biological processes such as...[Show more]
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