Differential activation of ion channels by inositol 1, 4, 5-trisphosphate (IP3)- and ryanodine-sensitive calcium stores in rat basilar artery vasomotion
Spontaneous, rhythmical contractions, or vasomotion, can be recorded from cerebral vessels under both normal physiological and pathophysiological conditions. Using electrophysiology to study changes in membrane potential, the ratiometric calcium indicator Fura-2 AM to study changes in [Ca2+]i in both the arterial wall and in individual smooth muscle cells (SMCs), and video microscopy to study changes in vessel diameter, we have investigated the cellular mechanisms underlying vasomotion in the...[Show more]
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|Source:||Journal of Physiology|
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