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Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor

Sandow, Shaun L; Tare, Marianne; Coleman, Harold; Hill, Caryl; Parkington, Helena


The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is controversial, putatively involving diffusible factors and/or electrotonic spread of hyperpolarization generated in the endothelium via myoendothelial gap junctions (MEGJs). In this study, we investigated the relationship between the existence of MEGJs, endothelial cell (EC) hyperpolarization, and EDHF-attributed smooth muscle cell (SMC) hyperpolarization in two different arteries: the rat mesenteric artery,...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Circulation Research
DOI: 10.1161/01.RES.0000019756.88731.83


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