Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system
During development the viability of immature neurons may depend upon retrograde, anterograde, or paracrine trophic support. Using125I-labeled peptides we show that there is substantial and rapid anterograde transport of brain-derived neurotrophic factor (BDNF) and, to a lesser extent, neurotrophin-4/5 (NT-4/5) to central visual target areas in the neonatal rat brain. Six hours after unilateral intraocular injection, all retinorecipient regions in the thalamus and midbrain are heavily labeled....[Show more]
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|Source:||Molecular and Cellular Neuroscience|
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