Spalding, Kirsty; Tan, M; Hendry, Ian; Hartunian, A
During development the viability of immature neurons may depend upon retrograde, anterograde, or paracrine trophic support. Using125I-labeled peptides we show that there is substantial and rapid anterograde transport of brain-derived neurotrophic factor (BDNF) and, to a lesser extent, neurotrophin-4/5 (NT-4/5) to central visual target areas in the neonatal rat brain. Six hours after unilateral intraocular injection, all retinorecipient regions in the thalamus and midbrain are heavily labeled....[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.