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Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system

Spalding, Kirsty; Tan, M; Hendry, Ian; Hartunian, A

Description

During development the viability of immature neurons may depend upon retrograde, anterograde, or paracrine trophic support. Using125I-labeled peptides we show that there is substantial and rapid anterograde transport of brain-derived neurotrophic factor (BDNF) and, to a lesser extent, neurotrophin-4/5 (NT-4/5) to central visual target areas in the neonatal rat brain. Six hours after unilateral intraocular injection, all retinorecipient regions in the thalamus and midbrain are heavily labeled....[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/71289
Source: Molecular and Cellular Neuroscience
DOI: 10.1006/mcne.2001.1097

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