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Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response

Mellor, Howard R.; Callaghan, Richard


Inherent and acquired resistance pathways account for the high rate of failure in cancer chemotherapy. The mechanisms or pathways mediating resistance may be classified as pharmacokinetic (i.e. alter intratumour drug exposue) or pharmacodynamic (i.e. failure to elicit cytotoxicity). More often than not, the resistant phenotype is characterised by alterations in multiple pathways. Consequently, the pathways may act synergistically or generate a broad spectrum of resistance to anticancer drugs....[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Pharmacology
DOI: 10.1159/000115967


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