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P-glycoprotein: So many ways to turn it on

Callaghan, Richard; Crowley, Emily; Potter, Simon; Kerr, Ian

Description

Expression of the ABC transporter P-glycoprotein (P-gp or ABCB1) is associated with resistance to chemotherapy in cancer. However, early investigations into the regulation of ABCB1 expression revealed that the process is not a classical induction as observed for certain metabolizing enzymes. The process involves the cellular stress response pathway initiated by either inflicted (eg, chemotherapy damage) or endogenous (eg, hypoxia) factors. However, ABCB1 is also expressed in a number of...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/71237
Source: Journal of Clinical Pharmacology
DOI: 10.1177/0091270007311568

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