Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
Background: Interleukin-13 is believed to be important in asthmatic inflammation and airway hyper-reactivity. Objective: To investigate the role of IL-13 in chronic asthma, using an improved experimental model of asthma that reproduces most of the morphological features of the human disease. Methods: BALB/c mice or gene-targeted mice deficient in their ability to produce IL-13 or the IL-4 receptor α-chain (IL-4Rα) were sensitized to ovalbumin and exposed to aerosolized antigen for 30 min/day on...[Show more]
|Collections||ANU Research Publications|
|Source:||Clinical and Experimental Allergy|
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