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Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma

Kumar, Rakesh K; Herbert, John; Yang, Ming; Koskinen, Aulikki; Mckenzie, Andrew N; Foster, Paul S

Description

Background: Interleukin-13 is believed to be important in asthmatic inflammation and airway hyper-reactivity. Objective: To investigate the role of IL-13 in chronic asthma, using an improved experimental model of asthma that reproduces most of the morphological features of the human disease. Methods: BALB/c mice or gene-targeted mice deficient in their ability to produce IL-13 or the IL-4 receptor α-chain (IL-4Rα) were sensitized to ovalbumin and exposed to aerosolized antigen for 30 min/day on...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/71227
Source: Clinical and Experimental Allergy
DOI: 10.1046/j.1365-2222.2002.01420.x

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