Soboleva, Tatiana; Nekrasov, Maxim; Ryan, Daniel; Tremethick, David
The function of a eukaryotic cell crucially depends on accurate gene transcription to ensure the right genes are expressed whereas unrequired genes are repressed. Therefore, arguably, one of the most important regions in the genome is the transcription start-site (TSS) of protein-coding and non-coding genes. Until recently, understanding the mechanisms that define the location of the TSS and how it is created has largely focused on the role of DNA sequence-specific transcription factors....[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.