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Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations

Rivers, Francesca; O'Brien, Terence J.; Callaghan, Richard


Approximately one-third of patients with epilepsy display an inherent resistance to pharmacological therapy, manifest as continuing seizures despite maximal tolerated doses of anti-epileptic drugs. One hypothesis for the underlying mechanism of anti-epileptic drug pharmacoresistance is lower drug entry to the epileptic neurones due to the activity of multidrug efflux pumps from the ATP Binding Cassette (ABC) superfamily at the blood-brain barrier. There has been a steady accumulation of animal...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: European Journal of Pharmacology
DOI: 10.1016/j.ejphar.2008.09.014


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