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Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

McDevitt, Christopher A.; Crowley, Emily; Hobbs, Gemma; Starr, Kate J.; Kerr, Ian; Callaghan, Richard

Description

ABCG2 confers resistance to cancer cells by mediating the ATP-dependent outward efflux of chemotherapeutic compounds. Recent studies have indicated that the protein contains a number of interconnected drug binding sites. The present investigation examines the coupling of drug binding to ATP hydrolysis. Initial drug binding to the protein requires a high-affinity interaction with the drug binding site, followed by transition and reorientation to the low-affinity state to enable dissociation at...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/71146
Source: The FEBS Journal
DOI: 10.1111/j.1742-4658.2008.06578.x

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