Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?
ABCG2 confers resistance to cancer cells by mediating the ATP-dependent outward efflux of chemotherapeutic compounds. Recent studies have indicated that the protein contains a number of interconnected drug binding sites. The present investigation examines the coupling of drug binding to ATP hydrolysis. Initial drug binding to the protein requires a high-affinity interaction with the drug binding site, followed by transition and reorientation to the low-affinity state to enable dissociation at...[Show more]
|Collections||ANU Research Publications|
|Source:||The FEBS Journal|
|01_McDevitt_Is_ATP_binding_responsible_for_2008.pdf||257.29 kB||Adobe PDF||Request a copy|
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