McDevitt, Christopher A.; Crowley, Emily; Hobbs, Gemma; Starr, Kate J.; Kerr, Ian; Callaghan, Richard
ABCG2 confers resistance to cancer cells by mediating the ATP-dependent outward efflux of chemotherapeutic compounds. Recent studies have indicated that the protein contains a number of interconnected drug binding sites. The present investigation examines the coupling of drug binding to ATP hydrolysis. Initial drug binding to the protein requires a high-affinity interaction with the drug binding site, followed by transition and reorientation to the low-affinity state to enable dissociation at...[Show more]
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