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Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

McDevitt, Christopher A.; Shintre, Chitra A.; Grossmann, J Gunter; Pollock, Naomi L.; Prince, Stephen; Callaghan, Richard; Ford, Robert C.

Description

P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/71144
Source: FEBS Letters
DOI: 10.1016/j.febslet.2008.07.022

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