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Cytosolic region of TM6 in P-glycoprotein: Topographical analysis and functional perturbation by site directed labeling

Storm, Janet; Modok, Szabolcs; O'Mara, Megan; Tieleman, D. Peter; Kerr, Ian; Callaghan, Richard


Reduced intracellular drug accumulation due to the activity of the drug efflux pump ABCB1 is a major mechanism in the resistance of cancer cells to chemotherapy. ABCB1 is a poly specific transporter, and the molecular mechanism of its complex translocation process remains to be elucidated. To understand the process will require information on the regions involved in drug binding and those that couple this event to nucleotide hydrolysis. The present investigation focuses on the cytosolic region...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Biochemistry
DOI: 10.1021/bi7023089


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