Looi, Jeffrey; Rajagopalan, Priya; Walterfang, Mark; Madsen, Sarah K; Thompson, Paul M; Macfarlane, Matthew; Ching, Chris; Chua, Phyllis; Velakoulis, Dennis
Objective: Direct neuronal loss or deafferentation of the putamen, a critical hub in corticostriatal circuits, may result in diverse and distinct cognitive and motoric dysfunction in neurodegenerative disease. Differential putaminal morphology, as a quantitative measure of corticostriatal integrity, may thus be evident in Huntingtons disease (HD), Alzheimers disease (AD) and frontotemporal dementia (FTD), diseases with differential clinical dysfunction. Methods: HD (n = 17), FTD (n = 33) and AD...[Show more]
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