Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis
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Mattner, F; Staykova, Maria; Berghofer, Paula; Wong, Heng Jian; Fordham, Susan; Callaghan, Paul; Jackson, Timothy; Pham, Tien; Gregoire, Marie-Claude; Zahra, David; Rahardjo, Gita; Linares Bandin, David; Katsifis, Andrew
Description
Glial neuroinflammation is associated with the development and progression of multiple sclerosis. PET imaging offers a unique opportunity to evaluate neuroinflammatory processes longitudinally in a noninvasive and clinically translational manner. 18FPBR111 is a newly developed PET radiopharmaceutical with high affinity and selectivity for the translocator protein (TSPO), expressed on activated glia. This study aimed to investigate neuroinflammation at different phases of relapsing-remitting...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/71084 |
Source: | European Journal of Nuclear Medicine and Molecular Imaging |
DOI: | 10.2967/jnumed.112.108894 |
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01_Mattner_Central_nervous_system_2013.pdf | 471.94 kB | Adobe PDF | Request a copy | |
02_Mattner_Central_nervous_system_2013.pdf | 471.94 kB | Adobe PDF | Request a copy |
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