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Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis

Mattner, F; Staykova, Maria; Berghofer, Paula; Wong, Heng Jian; Fordham, Susan; Callaghan, Paul; Jackson, Timothy; Pham, Tien; Gregoire, Marie-Claude; Zahra, David; Rahardjo, Gita; Linares Bandin, David; Katsifis, Andrew


Glial neuroinflammation is associated with the development and progression of multiple sclerosis. PET imaging offers a unique opportunity to evaluate neuroinflammatory processes longitudinally in a noninvasive and clinically translational manner. 18FPBR111 is a newly developed PET radiopharmaceutical with high affinity and selectivity for the translocator protein (TSPO), expressed on activated glia. This study aimed to investigate neuroinflammation at different phases of relapsing-remitting...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: European Journal of Nuclear Medicine and Molecular Imaging
DOI: 10.2967/jnumed.112.108894


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