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From brain determination to testis determination: Evolution of the mammalian sex-determining gene

Graves, Jennifer


In mammals, sex is determined by an XY male:XX female sex chromosome system in which a male-dominant gene on the Y chromosome (SRY) determines testis formation. Sex chromosomes evolved from an ordinary autosome pair as the Y chromosome was progressively degraded. The Y chromosome has lost nearly all of its 1500 original genes, and those that survived did so because they evolved a critical role in male determination or differentiation. SRY is typical of Y-borne genes. Comparative gene mapping...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Reproduction, Fertility and Development


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