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Use of observed within-person variation of cardiac troponin in emergency department patients for determination of biological variation and percentage and absolute reference change values

Simpson, Aaron J.; Potter, Julia; Koerbin, Gus; Oakman, C.; Cullen, L.; Wilkes, G.J.; Scanlan, S.L.; Parsonage, William; Hickman, Peter


BACKGROUND: Many patients presenting to the emergency department (ED) for assessment of possible acute coronary syndrome (ACS) have low cardiac troponin concentrations that change very little on repeat blood draw. It is unclear if a lack of change in cardiac troponin concentration can be used to identify acutely presenting patients at low risk of ACS. METHODS: We used the hs-cTnI assay from Abbott Diagnostics, which can detect cTnI in the blood of nearly all people. We identified a population...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Clinical Chemistry
DOI: 10.1373/clinchem.2013.219410


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