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Genetic distance for a general non-stationary markov substitution process

Kaehler, Benjamin; Yap, Von Bing; Zhang, Rongli; Huttley, Gavin Austin


The genetic distance between biological sequences is a fundamental quantity in molecular evolution. It pertains to questions of rates of evolution, existence of a molecular clock, and phylogenetic inference. Under the class of continuous-time substitution models, the distance is commonly defined as the expected number of substitutions at any site in the sequence. We eschew the almost ubiquitous assumptions of evolution under stationarity and time-reversible conditions and extend the concept of...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Systematic Biology
DOI: 10.1093/sysbio/syu106


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