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Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

Spillman, Natalie; Allen, Richard; McNamara, Case W.; Yeung, Bryan K.S.; Winzeler, Elizabeth A.; Diagana, Thierry T.; Kirk, Kiaran


The malaria parasite Plasmodium falciparum establishes in the host erythrocyte plasma membrane new permeability pathways that mediate nutrient uptake into the infected cell. These pathways simultaneously allow Na + influx, causing [Na+] in the infected erythrocyte cytosol to increase to high levels. The intraerythrocytic parasite itself maintains a low cytosolic [Na+] via unknown mechanisms. Here we present evidence that the intraerythrocytic parasite actively extrudes Na + against an inward...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Cell Host and Microbe
DOI: 10.1016/j.chom.2012.12.006


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