Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation
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Ajamieh, Hussam; Farrell, Geoffrey; McCuskey, Robert; Yu, Jun; Chu, Eagle; Wong, Heng; Lam, Wesley; Teoh, Narcissus
Description
Background & Aims: Steatosis accentuates the severity of hepatic ischaemia-reperfusion injury (IRI); 'statins' (HMG-CoA reductase inhibitors) protect the heart and brain against post-ischaemic injury. We tested whether short-term administration of atorvastatin protects fatty livers in obese mice against IRI. Methods: Mice with dietary or genetic simple steatosis (SS) or non-alcoholic steatohepatitis (NASH) were subjected to 60 min partial hepatic ischaemia/24 h reperfusion. Atorvastatin was...[Show more]
Collections | ANU Research Publications |
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Date published: | 2015 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/70834 |
Source: | Liver International |
DOI: | 10.1111/liv.12827 |
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01_Ajamieh_Acute_atorvastatin_is_2015.pdf | 2.24 MB | Adobe PDF | Request a copy |
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