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Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation

Ajamieh, Hussam; Farrell, Geoffrey; McCuskey, Robert; Yu, Jun; Chu, Eagle; Wong, Heng; Lam, Wesley; Teoh, Narcissus


Background & Aims: Steatosis accentuates the severity of hepatic ischaemia-reperfusion injury (IRI); 'statins' (HMG-CoA reductase inhibitors) protect the heart and brain against post-ischaemic injury. We tested whether short-term administration of atorvastatin protects fatty livers in obese mice against IRI. Methods: Mice with dietary or genetic simple steatosis (SS) or non-alcoholic steatohepatitis (NASH) were subjected to 60 min partial hepatic ischaemia/24 h reperfusion. Atorvastatin was...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Liver International
DOI: 10.1111/liv.12827


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