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Characterization of the Stability and Bio-functionality of Tethered Proteins on Bioengineered Scaffolds: Implications for stem cell biology and tissue repair

Wang, Ting-Yi; Bruggeman, Kiara; Sheean, Rebecca K; Turner, Bradley; Nisbet, David; Parish, Clare L.

Description

Background: Tethering proteins onto bioengineered scaffolds enables longterm delivery, however protein stability, release kinetics, and functionality over time remains unknown. Results: Tethered proteins remain stable and functional for several months, capable of activating intracellular signaling pathways and influencing cell fate. Conclusion: Tethered proteins are stable and functional long-term. Significance: Such knowledge may have implications for promoting tissue repair.

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/70806
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M113.537381

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