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Synaptic transmission in the auditory brainstem of normal and congenitally deaf mice

Oleskevich, Sharon; Walmsley, Bruce


The deafness (dn/dn) mutant mouse provides a valuable model of human congenital deafness. We investigated the properties of synaptic transmission in the anteroventral cochlear nucleus (AVCN) of normal and congenitally deaf dn/dn mice. Excitatory postsynaptic currents (EPSCs) were evoked by focal stimulation of single auditory nerve fibres, and measured by whole-cell recordings from neurones in AVCN slices (mean postnatal age = P13). Absolute amplitudes of both AMPA- and NMDA-mediated components...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2001.013821


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