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Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors

Hanna, Amy; Janczura , Marie; Cho, Eun; Dulhunty, Angela; Beard, Nicole


Our aim was to examine the Molecular basis for acute effects of the anthracycline daunorubicin on cardiac ryanodine receptor (RyR2) channels and cardiac calsequestrin (CSQ2). Cardiotoxic effects of anthracyclines preclude their chemotherapeutic use in patients with pre-existing heart conditions. To address this significant problem, the mechanisms of anthracycline toxicity must be defined but at present Are poorly understood. RyR2 channel activity was assessed by measuring Ca2+ release from...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Molecular Pharmacology
DOI: 10.1124/mol.111.073478


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