Hanna, Amy; Janczura , Marie; Cho, Eun; Dulhunty, Angela; Beard, Nicole
Our aim was to examine the Molecular basis for acute effects of the anthracycline daunorubicin on cardiac ryanodine receptor (RyR2) channels and cardiac calsequestrin (CSQ2). Cardiotoxic effects of anthracyclines preclude their chemotherapeutic use in patients with pre-existing heart conditions. To address this significant problem, the mechanisms of anthracycline toxicity must be defined but at present Are poorly understood. RyR2 channel activity was assessed by measuring Ca2+ release from...[Show more]
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