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Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice

Licon Luna, Rosa; Lee, Eva; Mullbacher, Arno; Blanden, Robert; Langman, Rod; Lobigs, Mario


The mechanism by which encephalitic flaviviruses enter the brain to inflict a life-threatening encephalomyelitis in a small percentage of infected individuals is obscure. We investigated this issue in a mouse model for flavivirus encephalitis in which the virus was administered to 6-week-old animals by the intravenous route, analogous to the portal of entry in natural infections, using a virus dose in the range experienced following the bite of an infectious mosquito. In this model, infection...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.76.7.3202-3211.2002


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