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Foxp3+ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis

Tian, Lei; Altin, John; Makaroff, Lydia E.; Franckaert, Dean; Cook, Matthew; Goodnow, Christopher; Dooley, James; Liston, Adrian


Foxp3+ regulatory T cells play a pivotal role in maintaining self-tolerance and immune homeostasis. In the absence of regulatory T cells, generalized immune activation and multiorgan T cell-driven pathology occurs. Although the phenomenon of immunologic control by Foxp3+ regulatory T cells is well recognized, the comparative effect over different arms of the immune system has not been thoroughly investigated. Here, we generated a cohort of mice with a continuum of regulatory T-cell frequencies...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2011-04-346056


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