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Effectiveness of beads for tracking small-scale molecular motor dynamics

Lade, Steven; Craig, Erin M; Linke, Heiner


Investigations into molecular motor dynamics are increasingly focused on small-scale features of the motor's motion. We define performance measures of a common type of single-molecule motility assay, the bead assay, for its ability to detect such features. Using numerical models, we explore the dependence of assay performance on a number of experimentally controllable parameters, including bead size, optical force, and the method of attaching the bead to the motor. We find that the best...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Physical Review E-Statistical, Nonlinear and Soft Matter Physics
DOI: 10.1103/PhysRevE.84.021907


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