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Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals

Tsukamoto, Kentaro; Deakin, Janine; Graves, Jennifer A. Marshall; Hashimoto, Keiichiro

Description

The major histocompatibility complex (MHC) class I-related gene, MR1, is a non-classical MHC class IA gene and is encoded outside the MHC region. The MR1 is responsible for activation of mucosal-associated invariant T (MAIT) cells expressing semi-invariant T cell receptors in the presence of bacteria, but its ligand has not been identified. A unique characteristic of MR1 is its high evolutionary conservation of the α1 and α2 domains corresponding to the peptide-binding domains of classical MHC...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/70518
Source: Immunogenetics
DOI: 10.1007/s00251-012-0666-5

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