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Eotaxin Expression by Epithelial Cells and Plasma Cells in Chronic Asthma

Kumar, Rakesh K; Thomas, Paul S; Seetoo, Da-Qiang; Herbert, John; Mckenzie, Andrew N; Foster, Paul S; Lloyd, Andrew

Description

Chemoattractants such as eotaxin are believed to play an important role in the recruitment of eosinophils into the airways in asthma. We investigated expression of eotaxin in the airway wall in a model of chronic human asthma, in which systemically sensitized mice were exposed to low mass concentrations of aerosolized antigen for 6 weeks. In these animals, the number of intraepithelial eosinophils in the airways was significantly increased 3 hours after exposure and declined by 24 hours. In...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/70505
Source: Laboratory Investigation

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