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Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels

Hilder, Tamsyn; Corry, Ben; Chung, Shin-Ho


There is clear evidence that the net magnitude of negative charge at the intracellular end of inwardly rectifying potassium channels helps to generate an asymmetry in the magnitude of the current that will pass in each direction. However, a complete understanding of the physical mechanism that links these charges to current rectification has yet to be obtained. Using Brownian dynamics, we compare the conduction mechanism and binding sites in rectifying and non-rectifying channel models. We find...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Biological Physics
DOI: 10.1007/s10867-013-9338-4


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