Foxp3+ follicular regulatory T cells control the germinal center response
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Linterman, Michelle; Pierson, Wim; Lee, Sau Kuen (Candice); Kallies, Axel; Kawamoto, Shimpei; Rayner, Tim E; Srivastava, Monika; Divekar, Devina P; Beaton, Laura; Hogan, Jennifer; Fagarasan, Sidonia; Liston, Adrian; Smith, Kenneth GC; Garcia De Vinuesa, Maria Carola
Description
Follicular helper (T FH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of T FH numbers maintains self tolerance. We describe a population of Foxp3 + Blimp-1 + CD4 + T cells constituting 10-25% of the CXCR5 high PD-1 high CD4 + T cells found in the germinal center after immunization with protein antigens. These follicular regulatory T (T FR) cells share phenotypic characteristics with T...[Show more]
dc.contributor.author | Linterman, Michelle | |
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dc.contributor.author | Pierson, Wim | |
dc.contributor.author | Lee, Sau Kuen (Candice) | |
dc.contributor.author | Kallies, Axel | |
dc.contributor.author | Kawamoto, Shimpei | |
dc.contributor.author | Rayner, Tim E | |
dc.contributor.author | Srivastava, Monika | |
dc.contributor.author | Divekar, Devina P | |
dc.contributor.author | Beaton, Laura | |
dc.contributor.author | Hogan, Jennifer | |
dc.contributor.author | Fagarasan, Sidonia | |
dc.contributor.author | Liston, Adrian | |
dc.contributor.author | Smith, Kenneth GC | |
dc.contributor.author | Garcia De Vinuesa, Maria Carola | |
dc.date.accessioned | 2015-12-13T22:15:34Z | |
dc.identifier.issn | 1078-8956 | |
dc.identifier.uri | http://hdl.handle.net/1885/70466 | |
dc.description.abstract | Follicular helper (T FH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of T FH numbers maintains self tolerance. We describe a population of Foxp3 + Blimp-1 + CD4 + T cells constituting 10-25% of the CXCR5 high PD-1 high CD4 + T cells found in the germinal center after immunization with protein antigens. These follicular regulatory T (T FR) cells share phenotypic characteristics with T FH and conventional Foxp3 + regulatory T (T reg) cells yet are distinct from both. Similar to T FH cells, T FR cell development depends on Bcl-6, SLAM-associated protein (SAP), CD28 and B cells; however, T FR cells originate from thymic-derived Foxp3 + precursors, not naive or T FH cells. T FR cells are suppressive in vitro and limit T FH cell and germinal center B cell numbers in vivo. In the absence of T FR cells, an outgrowth of non-antigen-specific B cells in germinal centers leads to fewer antigen-specific cells. Thus, the T FH differentiation pathway is co-opted by T reg cells to control the germinal center response. | |
dc.publisher | Nature Publishing Group | |
dc.source | Nature Medicine | |
dc.subject | Keywords: B lymphocyte induced maturation protein 1; CD28 antigen; chemokine receptor CXCR5; protein bcl 6; signaling lymphocyte activation molecule associated protein; transcription factor FOXP3; animal cell; animal experiment; animal model; animal tissue; article | |
dc.title | Foxp3+ follicular regulatory T cells control the germinal center response | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 17 | |
dc.date.issued | 2011 | |
local.identifier.absfor | 110705 - Humoural Immunology and Immunochemistry | |
local.identifier.absfor | 110703 - Autoimmunity | |
local.identifier.absfor | 110704 - Cellular Immunology | |
local.identifier.ariespublication | f2965xPUB2320 | |
local.type.status | Published Version | |
local.contributor.affiliation | Linterman, Michelle, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Pierson, Wim, Catholic University of Leuven | |
local.contributor.affiliation | Lee, Sau Kuen (Candice), College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Kallies, Axel, Walter and Eliza Hall Institute of Medical Research | |
local.contributor.affiliation | Kawamoto, Shimpei, Riken Research Center for Allergy and Immunology | |
local.contributor.affiliation | Rayner, Tim E, University of Cambridge School of Clinical Medicine | |
local.contributor.affiliation | Srivastava, Monika, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Divekar, Devina P, University of Cambridge School of Clinical Medicine | |
local.contributor.affiliation | Beaton, Laura, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Hogan, Jennifer, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Fagarasan, Sidonia, Riken Research Center for Allergy and Immunology | |
local.contributor.affiliation | Liston, Adrian , University of Leuven | |
local.contributor.affiliation | Smith, Kenneth GC, University of Cambridge School of Clinical Medicine | |
local.contributor.affiliation | Garcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 8 | |
local.bibliographicCitation.startpage | 975 | |
local.bibliographicCitation.lastpage | 982 | |
local.identifier.doi | 10.1038/nm.2425 | |
local.identifier.absseo | 920108 - Immune System and Allergy | |
dc.date.updated | 2016-02-24T08:25:03Z | |
local.identifier.scopusID | 2-s2.0-79961151137 | |
local.identifier.thomsonID | 000293507400031 | |
Collections | ANU Research Publications |
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