Foxp3+ follicular regulatory T cells control the germinal center response
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Linterman, Michelle; Pierson, Wim; Lee, Sau Kuen (Candice); Kallies, Axel; Kawamoto, Shimpei; Rayner, Tim E; Srivastava, Monika; Divekar, Devina P; Beaton, Laura; Hogan, Jennifer; Fagarasan, Sidonia; Liston, Adrian; Smith, Kenneth GC; Garcia De Vinuesa, Maria Carola
Description
Follicular helper (T FH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of T FH numbers maintains self tolerance. We describe a population of Foxp3 + Blimp-1 + CD4 + T cells constituting 10-25% of the CXCR5 high PD-1 high CD4 + T cells found in the germinal center after immunization with protein antigens. These follicular regulatory T (T FR) cells share phenotypic characteristics with T...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/70466 |
Source: | Nature Medicine |
DOI: | 10.1038/nm.2425 |
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File | Description | Size | Format | Image |
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01_Linterman_Foxp3+_follicular_regulatory_T_2011.pdf | 1.41 MB | Adobe PDF | Request a copy |
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