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Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, Michelle; Pierson, Wim; Lee, Sau Kuen (Candice); Kallies, Axel; Kawamoto, Shimpei; Rayner, Tim E; Srivastava, Monika; Divekar, Devina P; Beaton, Laura; Hogan, Jennifer; Fagarasan, Sidonia; Liston, Adrian; Smith, Kenneth GC; Garcia De Vinuesa, Maria Carola


Follicular helper (T FH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of T FH numbers maintains self tolerance. We describe a population of Foxp3 + Blimp-1 + CD4 + T cells constituting 10-25% of the CXCR5 high PD-1 high CD4 + T cells found in the germinal center after immunization with protein antigens. These follicular regulatory T (T FR) cells share phenotypic characteristics with T...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Nature Medicine
DOI: 10.1038/nm.2425


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