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Distinct haplotype structure at the innate immune receptor Toll-like receptor 2 across bank vole populations and lineages in Europe

Morger, Jennifer; Raberg, Lars; Hille, Sabine Marlene; Helsen, Sanne; Stefka, Jan; Mohammad, Al-Sabi; Kapel, Christian; Mappes, Tapio; Essbauer, Sandra; Ulrich, Rainer; Bartolommei, P.; Mortelliti, Alessio


Parasite-mediated selection may contribute to the maintenance of genetic variation at host immune genes over long time scales. To date, the best evidence for the long-term maintenance of immunogenetic variation in natural populations comes from studies on the major histocompatibility complex (MHC) genes, whereas evidence for such processes from other immune genes remains scarce. In the present study, we show that, despite pronounced population differentiation and the occurrence of numerous...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Biological Journal of the Linnean Society
DOI: 10.1111/bij.12593


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