Lechner, Bettina; Rashbrooke, Madeleine; Collings, David; Eng, Ryan C; Kawamura, Eiko; Whittington, A; Wasteneys, Geoffrey
Microtubule-associated proteins of the highly conserved XMAP215/Dis1 family promote both microtubule growth and shrinkage, and move with the dynamic microtubule ends. The plant homologue, MOR1, is predicted to form a long linear molecule with five N-terminal TOG domains. Within the first (TOG1) domain, the mor1-1 leucine to phenylalanine (L174F) substitution causes temperature-dependent disorganization of microtubule arrays and reduces microtubule growth and shrinkage rates. By expressing the...[Show more]
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