Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation
Abed, Hany S.; Samuel, Chrishan S; Lau, Dennis H; Kelly, Darren J; Royce, Simon G; Alasady, Muayad; Mahajan, Rajiv; Kuklik, Pawel; Abhayaratna, Walter; Kalman, Jonathan M.; Sanders, Prashanthan; Brooks, A; Nelson, Adam J; Wittert, Gary A.
Background: Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown. Objective: To examine the effect of progressive weight gain on the substrate for AF. Methods: Thirty sheep were studied at baseline, 4 months, and 8 months, following a high-calorie diet. Ten sheep were sampled at each time point for cardiac magnetic resonance imaging and hemodynamic studies. High-density multisite biatrial epicardial mapping was used to quantify...[Show more]
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