Skip navigation
Skip navigation

GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway

Menon, Deepthi; Coll, Rebecca; O'Neill, Luke A J; Board, Philip

Description

Macrophagesmediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and reactive oxygen species (ROS). LPS activation also skews the metabolism ofmacrophages towards a glycolytic phenotype. Here, we demonstrate that the LPS-triggered glycolytic switch is significantly attenuated in macrophages deficient for glutathione transferase omega-1 (GSTO1,...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/70299
Source: Journal of Cell Science
DOI: 10.1242/jcs.167858

Download

File Description SizeFormat Image
01_Menon_GSTO1-1_modulates_metabolism_2015.pdf1.06 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator