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GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway

Menon, Deepthi; Coll, Rebecca; O'Neill, Luke A J; Board, Philip


Macrophagesmediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and reactive oxygen species (ROS). LPS activation also skews the metabolism ofmacrophages towards a glycolytic phenotype. Here, we demonstrate that the LPS-triggered glycolytic switch is significantly attenuated in macrophages deficient for glutathione transferase omega-1 (GSTO1,...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.167858
Access Rights: Open Access


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