GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway
Macrophagesmediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and reactive oxygen species (ROS). LPS activation also skews the metabolism ofmacrophages towards a glycolytic phenotype. Here, we demonstrate that the LPS-triggered glycolytic switch is significantly attenuated in macrophages deficient for glutathione transferase omega-1 (GSTO1,...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Cell Science|
|01_Menon_GSTO1-1_modulates_metabolism_2015.pdf||1.06 MB||Adobe PDF|
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