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Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

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Summers, Robert; Dave, Anurag; Dolstra, Tegan; Bellanca, Sebastiano; Marchetti, Rosa; Nash, Megan; Richards, Sashika; Goh, Xin-Lin; Schenk, Robyn; Stein, Wilfred D.; Kirk, Kiaran; Sanchez, Cecilia P.; Lanzer, Michael; Martin, Rowena

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Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given

dc.contributor.authorSummers, Robert
dc.contributor.authorDave, Anurag
dc.contributor.authorDolstra, Tegan
dc.contributor.authorBellanca, Sebastiano
dc.contributor.authorMarchetti, Rosa
dc.contributor.authorNash, Megan
dc.contributor.authorRichards, Sashika
dc.contributor.authorGoh, Xin-Lin
dc.contributor.authorSchenk, Robyn
dc.contributor.authorStein, Wilfred D.
dc.contributor.authorKirk, Kiaran
dc.contributor.authorSanchez, Cecilia P.
dc.contributor.authorLanzer, Michael
dc.contributor.authorMartin, Rowena
dc.date.accessioned2015-12-10T23:36:49Z
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/1885/70294
dc.description.abstractMutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given
dc.publisherNational Academy of Sciences (USA)
dc.rightsAuthor/s retain copyright
dc.sourceNational Academy of Sciences. Proceedings
dc.titleDiverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume111
dc.date.issued2014
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absfor110803 - Medical Parasitology
local.identifier.absfor030401 - Biologically Active Molecules
local.identifier.ariespublicationU3488905xPUB2281
local.type.statusPublished Version
local.contributor.affiliationSummers, Robert, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDave, Anurag, Universitatsklinikum Heidelberg
local.contributor.affiliationDolstra, Tegan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBellanca, Sebastiano, Universitatsklinikum Heidelberg
local.contributor.affiliationMarchetti, Rosa, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationNash, Megan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRichards, Sashika, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoh, Xin-Lin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSchenk, Robyn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationStein, Wilfred D., The Hebrew University of Jerusalem
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSanchez, Cecilia P., Universitatsklinikum Heidelberg
local.contributor.affiliationLanzer, Michael, Universitatsklinikum Heidelberg
local.contributor.affiliationMartin, Rowena, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue17
local.bibliographicCitation.startpageE1759
local.bibliographicCitation.lastpageE1767
local.identifier.doi10.1073/pnas.1322965111
local.identifier.absseo920109 - Infectious Diseases
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
dc.date.updated2015-12-10T11:57:14Z
local.identifier.scopusID2-s2.0-84899651699
local.identifier.thomsonID000335199000014
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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