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Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

Summers, Robert; Dave, Anurag; Dolstra, Tegan; Bellanca, Sebastiano; Marchetti, Rosa; Nash, Megan; Richards, Sashika; Goh, Xin-Lin; Schenk, Robyn; Stein, Wilfred D.; Kirk, Kiaran; Sanchez, Cecilia P.; Lanzer, Michael; Martin, Rowena

Description

Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/70294
Source: National Academy of Sciences. Proceedings
DOI: 10.1073/pnas.1322965111

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