Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter
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Summers, Robert; Dave, Anurag; Dolstra, Tegan; Bellanca, Sebastiano; Marchetti, Rosa; Nash, Megan; Richards, Sashika; Goh, Xin-Lin; Schenk, Robyn; Stein, Wilfred D.; Kirk, Kiaran; Sanchez, Cecilia P.; Lanzer, Michael; Martin, Rowena
Description
Mutations in the chloroquine resistance transporter (PfCRT) are the primary determinant of chloroquine (CQ) resistance in the malaria parasite Plasmodium falciparum. A number of distinct PfCRT haplotypes, containing between 4 and 10 mutations, have given
| Collections | ANU Research Publications |
|---|---|
| Date published: | 2014 |
| Type: | Journal article |
| URI: | http://hdl.handle.net/1885/70294 |
| Source: | National Academy of Sciences. Proceedings |
| DOI: | 10.1073/pnas.1322965111 |
| Access Rights: | Open Access |
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| File | Description | Size | Format | Image |
|---|---|---|---|---|
| 01_Summers_Diverse_mutational_pathways_2014.pdf | 1.47 MB | Adobe PDF | ||
| 02_Summers_Diverse_mutational_pathways_2014.pdf | 1.48 MB | Adobe PDF |
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