Skip navigation
Skip navigation

Current work and future possibilities for the management of severe influenza: Using immunomodulatory agents that target the host response

Alleva, Lisa; Gualano, Rosa C; Clark, Ian A


In this article, we argue the case that the excessive inflammatory response seen in severe influenza contributes to severe illness and death by disabling oxidative phosphorylation in mitochondria, leading to reduced cellular levels of ATP. When the mitochondrial permeability transition is induced, cells cannot die by apoptosis in the face of reduced ATP levels, because apoptosis depends upon ATP availability, and so cells undergo necrosis. Cellular necrosis causes release of proinflammatory...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Future Virology
DOI: 10.2217/fvl.11.51


File Description SizeFormat Image
01_Alleva_Current_work_and_future_2011.pdf959.71 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator