B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
Lee, Sau Kuen (Candice); Rigby, Robert; Zotos, Dimitra; Tsai, Louis M; Kawamoto, Shimpei; Marshall, Jennifer; Ramiscal, Roy; Chan, Tyani D.; Gatto, Dominique; Brink, Robert; Yu, Di; Fagarasan, Sidonia; Tarlinton, David M.; Cunningham, Adam F; Garcia De Vinuesa, Maria Carola; Chan, Tyani
T follicular helper cells (Tfh cells) localize to follicles where they provide growth and selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation into high affinity long-lived plasma cells and memory B cells. T-dependent B cell differentiation also occurs extrafollicularly, giving rise to unmutated plasma cells that are important for early protection against microbial infections. Bcl-6 expression in T cells has been shown to be essential for the formation...[Show more]
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|Source:||Journal of Experimental Medicine|
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