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Evolutionary origins of a bioactive peptide buried within Preproalbumin

Elliott, Alysha G; Delay, Christina; Liu, Huanli; Phua, Zaiyang; Rosengren, K. Johan; Benfield, Aurélie H.; Panero, Jose L.; Colgrave, Michelle L; Jayasena, Achala S.; Dunse, Kerry M.; Anderson, Marilyn; Schilling, Edward E.


The de novo evolution of proteins is now considered a frequented route for biological innovation, but the genetic and biochemical processes that lead to each newly created protein are often poorly documented. The common sunflower (Helianthus annuus) contains the unusual gene PawS1 (Preproalbumin with SFTI-1) that encodes a precursor for seed storage albumin; however, in a region usually discarded during albumin maturation, its sequence is matured into SFTI-1, a protease-inhibiting cyclic...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: The Plant Cell
DOI: 10.1105/tpc.114.123620


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