Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster
The Rho GTP exchange factor, Pebble (Pbl), long recognised as an essential activator of Rho during cytokinesis, also regulates mesoderm migration at gastrulation. Like other cell cycle components, pbl expression patterns broadly correlate with proliferative tissue. Surprisingly, in spite of its role in the early mesoderm, pbl is downregulated in the presumptive mesoderm before ventral furrow formation. Here, we show that this mesoderm-specific repression of pbl is dependent on the...[Show more]
|Collections||ANU Research Publications|
|Source:||Development Genes and Evolution|
|01_Murray_Snail-dependent_repression_of_2012.pdf||555.03 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.