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Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster

Murray, Michael; Southall, Tony D.; Liu, Wenjie; Fraval, Hamilton; Lorensuhewa, Nirmal; Brand, Andrea H; Saint, Robert


The Rho GTP exchange factor, Pebble (Pbl), long recognised as an essential activator of Rho during cytokinesis, also regulates mesoderm migration at gastrulation. Like other cell cycle components, pbl expression patterns broadly correlate with proliferative tissue. Surprisingly, in spite of its role in the early mesoderm, pbl is downregulated in the presumptive mesoderm before ventral furrow formation. Here, we show that this mesoderm-specific repression of pbl is dependent on the...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Development Genes and Evolution
DOI: 10.1007/s00427-012-0414-8


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