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Accelerated Maturation and Abnormal Morphology in the Preterm Neonatal Kidney

Sutherland, Megan R; Gubhaju, Lina; Moore, Lynette; Kent, Alison; Dahlstrom, Jane; Horne, Rosemary S. C.; Hoy, Wendy E.; Bertram, John; Black, M. Jane


Nephrogenesis is ongoing at the time of birth for the majority of preterm infants, but whether postnatal renal development follows a similar trajectory to normal in utero growth is unknown. Here, we examined tissue collected at autopsy from 28 kidneys from preterm neonates, whose postnatal survival ranged from 2 to 68 days, including 6 that had restricted intrauterine growth. In addition, we examined kidneys from 32 still-born gestational controls. We assessed the width of the nephrogenic zone,...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of the American Society of Nephrology
DOI: 10.1681/ASN.2010121266


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