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Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter

Petersen, Ines; Gabryszewski, Stanislaw J; Johnston, Geoffrey L; Dhingra, Satish K; Ecker, A; Lewis, Rebecca E; De Almeida, Mariana Justino; Straimer, Judith; Henrich, Philipp P.; Palatulan, Eugene; Lehane, Adele


The widespread use of chloroquine to treat Plasmodium falciparum infections has resulted in the selection and dissemination of variant haplotypes of the primary resistance determinant PfCRT. These haplotypes have encountered drug pressure and within-host

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Molecular Microbiology
DOI: 10.1111/mmi.13035


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