Skip navigation
Skip navigation

Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function

Brownlie , Rebecca J; Miosge, Lisa; Vassilakos, Demetrios; Svensson, Lena M.; Cope, Andrew; Zamoyska, Rose


The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that the total number of lymphocytes in the periphery remains relatively constant. Mutations in PTPN22 confer an increased risk of developing autoimmune diseases; however, the precise function of PTPN22 and how mutations contribute to autoimmunity remain controversial. Loss-of-function mutations in PTPN22 are associated with increased numbers...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Science Signaling
DOI: 10.1126/scisignal.2003365


File Description SizeFormat Image
01_Brownlie _Lack_of_the_phosphatase_PTPN22_2012.pdf1.36 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator