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Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function

Brownlie , Rebecca J; Miosge, Lisa; Vassilakos, Demetrios; Svensson, Lena M.; Cope, Andrew; Zamoyska, Rose

Description

The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that the total number of lymphocytes in the periphery remains relatively constant. Mutations in PTPN22 confer an increased risk of developing autoimmune diseases; however, the precise function of PTPN22 and how mutations contribute to autoimmunity remain controversial. Loss-of-function mutations in PTPN22 are associated with increased numbers...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/70135
Source: Science Signaling
DOI: 10.1126/scisignal.2003365

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