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Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production

Jeelall, Yogeshraj; Wang, James; Law, Hsei-Di; Domaschenz, Heather; Fung, Herman; Kallies, Axel; Nutt, Stephen L; Goodnow, Christopher; Horikawa, Keisuke


Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigenbinding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from a single molecular change. By introducing individual CARD11 mutations found in human lymphomas into antigen-activated mature B lymphocytes in...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20112744
Access Rights: Open Access


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