Hsu, Peter; Santner-Nanan, Brigitte; Dahlstrom, Jane; Fadia, Mitali; Chandra, Arin; Peek, Michael; Nanan, Ralph
Regulatory T (Treg) cell expansion is required for tolerance of the semi-allogeneic fetus in healthy pregnancy and impaired in preeclampsia in humans. However, the reasons remain unknown. Herein, we show that expansion of CD4+Helios-Foxp3+ adaptive Treg (iTreg) cells, rather than CD4+Helios+Foxp3+ natural Treg cells, accounts for this expansion in healthy pregnancy. This expansion is even more pronounced in the decidua, where there is an overrepresentation of iTreg cells. In preeclampsia,...[Show more]
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