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Altered decidual DC-SIGN + antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia

Hsu, Peter; Santner-Nanan, Brigitte; Dahlstrom, Jane; Fadia, Mitali; Chandra, Arin; Peek, Michael; Nanan, Ralph

Description

Regulatory T (Treg) cell expansion is required for tolerance of the semi-allogeneic fetus in healthy pregnancy and impaired in preeclampsia in humans. However, the reasons remain unknown. Herein, we show that expansion of CD4+Helios-Foxp3+ adaptive Treg (iTreg) cells, rather than CD4+Helios+Foxp3+ natural Treg cells, accounts for this expansion in healthy pregnancy. This expansion is even more pronounced in the decidua, where there is an overrepresentation of iTreg cells. In preeclampsia,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/70054
Source: American Journal of Pathology
DOI: 10.1016/j.ajpath.2012.08.032

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