Skip navigation
Skip navigation

Altered decidual DC-SIGN + antigen-presenting cells and impaired regulatory T-cell induction in preeclampsia

Hsu, Peter; Santner-Nanan, Brigitte; Dahlstrom, Jane; Fadia, Mitali; Chandra, Arin; Peek, Michael; Nanan, Ralph


Regulatory T (Treg) cell expansion is required for tolerance of the semi-allogeneic fetus in healthy pregnancy and impaired in preeclampsia in humans. However, the reasons remain unknown. Herein, we show that expansion of CD4+Helios-Foxp3+ adaptive Treg (iTreg) cells, rather than CD4+Helios+Foxp3+ natural Treg cells, accounts for this expansion in healthy pregnancy. This expansion is even more pronounced in the decidua, where there is an overrepresentation of iTreg cells. In preeclampsia,...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: American Journal of Pathology
DOI: 10.1016/j.ajpath.2012.08.032


File Description SizeFormat Image
01_Hsu_Altered_decidual_DC-SIGN_+__2012.pdf2.61 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator