Howitt, Lauren; Morris, Margaret J.; Sandow, Shaun, L; Murphy, Timothy V.
This study examined the effect of diet-induced obesity on the functional role of large-conductance Ca2+-activated K+ channels (BKCa) in rat middle cerebral arteries. Male Sprague-Dawley rats were fed a control (chow) or high-fat diet for 16-20weeks. Diet-induced obesity decreased maximum bradykinin-induced dilation of isolated, pressurized (80mmHg) arteries, but vasodilation induced by sodium nitroprusside (SNP) was unaltered. Responses to bradykinin and SNP in arteries from both control and...[Show more]
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