Skip navigation
Skip navigation

Effect of diet-induced obesity on BKCa function in contraction and dilation of rat isolated middle cerebral artery

Howitt, Lauren; Morris, Margaret J.; Sandow, Shaun, L; Murphy, Timothy V.


This study examined the effect of diet-induced obesity on the functional role of large-conductance Ca2+-activated K+ channels (BKCa) in rat middle cerebral arteries. Male Sprague-Dawley rats were fed a control (chow) or high-fat diet for 16-20weeks. Diet-induced obesity decreased maximum bradykinin-induced dilation of isolated, pressurized (80mmHg) arteries, but vasodilation induced by sodium nitroprusside (SNP) was unaltered. Responses to bradykinin and SNP in arteries from both control and...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Vascular Pharmacology
DOI: 10.1016/j.vph.2014.02.002


File Description SizeFormat Image
01_Howitt_Effect_of_diet-induced_obesity_2014.pdf604.03 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator