Mechanism of tetrodotoxin block and resistance in sodium channels
Tetrodotoxin (TTX) has been used for many decades to characterize the structure and function of biological ion channels. Yet, the precise mechanism by which TTX blocks voltage-gated sodium (NaV) channels is not fully understood. Here molecular dynamics simulations are used to elucidate how TTX blocks mammalian voltage-gated sodium (Nav) channels and why it fails to be effective for the bacterial sodium channel, NaVAb. We find that, in NaVAb, a sodium ion competes with TTX for the binding site...[Show more]
|Collections||ANU Research Publications|
|Source:||Biochemical and Biophysical Research Communications|
|01_Chen_Mechanism_of_tetrodotoxin_2014.pdf||849.29 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.