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Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells

Yin, Li; Song, Jian; Board, Philip; Yu, Yang; Han, Xiao; Wei, Jingyan


Accumulating evidence shows that glutathione peroxidase (GPX, EC., one of the most important antioxidant selenoenzymes, plays an essential role in protecting cells and tissues against oxidative damage by catalyzing the reduction of hydrogen peroxide by glutathione. Unfortunately, because of the limited availability and poor stability of GPX, it has not been used clinically to protect against oxidative stress. To overcome these problems, it is necessary to generate mimics of GPX. In...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Journal of Molecular Recognition
DOI: 10.1002/jmr.2241


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