Regulation of the cardiac muscle ryanodine receptor by glutathione transferases
Glutathione transferases (GSTs) are generally recognized for their role in phase II detoxification reactions. However, it is becoming increasingly apparent that members of the GST family also have a diverse range of other functions that are, in general, unrelated to detoxification. One such action is a specific inhibition of the cardiac isoform of the ryanodine receptor (RyR2) intracellular Ca2+ release channel. In this review, we compare functional and physical interactions between members of...[Show more]
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|Source:||Drug Metabolism Reviews|
|01_Dulhunty_Regulation_of_the_cardiac_2011.pdf||1.38 MB||Adobe PDF||Request a copy|
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