Dulhunty, Angela; Hewawasam, Ruwani; Liu, Dan; Casarotto, Marco; Board, Philip
Glutathione transferases (GSTs) are generally recognized for their role in phase II detoxification reactions. However, it is becoming increasingly apparent that members of the GST family also have a diverse range of other functions that are, in general, unrelated to detoxification. One such action is a specific inhibition of the cardiac isoform of the ryanodine receptor (RyR2) intracellular Ca2+ release channel. In this review, we compare functional and physical interactions between members of...[Show more]
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