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Regulation of the cardiac muscle ryanodine receptor by glutathione transferases

Dulhunty, Angela; Hewawasam, Ruwani; Liu, Dan; Casarotto, Marco; Board, Philip

Description

Glutathione transferases (GSTs) are generally recognized for their role in phase II detoxification reactions. However, it is becoming increasingly apparent that members of the GST family also have a diverse range of other functions that are, in general, unrelated to detoxification. One such action is a specific inhibition of the cardiac isoform of the ryanodine receptor (RyR2) intracellular Ca2+ release channel. In this review, we compare functional and physical interactions between members of...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/69850
Source: Drug Metabolism Reviews
DOI: 10.3109/03602532.2010.549134

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